The N–Terminal Tail of hERG Contains an Amphipathic α–Helix That Regulates Channel Deactivation

The cytoplasmic N–terminal domain of the human ether–a–go–go related gene (hERG) K(+) channel is critical for the slow deactivation kinetics of the channel. However, the mechanism(s) by which the N–terminal domain regulates deactivation remains to be determined. Here we show that the solution NMR st...

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Detalles Bibliográficos
Autores principales: Ng, Chai Ann, Hunter, Mark J., Perry, Matthew D., Mobli, Mehdi, Ke, Ying, Kuchel, Philip W., King, Glenn F., Stock, Daniela, Vandenberg, Jamie I.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020963/
https://www.ncbi.nlm.nih.gov/pubmed/21249148
http://dx.doi.org/10.1371/journal.pone.0016191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020963/
https://www.ncbi.nlm.nih.gov/pubmed/21249148
http://dx.doi.org/10.1371/journal.pone.0016191

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