Steroids Up-Regulate p66Shc Longevity Protein in Growth Regulation by Inhibiting Its Ubiquitination

BACKGROUND: p66Shc, an isoform of Shc adaptor proteins, mediates diverse signals, including cellular stress and mouse longevity. p66Shc protein level is elevated in several carcinomas and steroid-treated human cancer cells. Several lines of evidence indicate that p66Shc plays a critical role in ster...

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Detalles Bibliográficos
Autores principales: Kumar, Santosh, Kumar, Satyendra, Rajendran, Mythilypriya, Alam, Syed Mahfuzul, Lin, Fen-Fen, Cheng, Pi-Wan, Lin, Ming-Fong
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021521/
https://www.ncbi.nlm.nih.gov/pubmed/21264241
http://dx.doi.org/10.1371/journal.pone.0015942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021521/
https://www.ncbi.nlm.nih.gov/pubmed/21264241
http://dx.doi.org/10.1371/journal.pone.0015942

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