Survivin Selectively Modulates Genes Deregulated in Human Leukemia Stem Cells

ITD-Flt3 mutations are detected in leukemia stem cells (LSCs) in acute myeloid leukemia (AML) patients. While antagonizing Survivin normalizes ITD-Flt3-induced acute leukemia, it also impairs hematopoietic stem cell (HSC) function, indicating that identification of differences in signaling pathways...

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Detalles Bibliográficos
Autores principales: Fukuda, Seiji, Abe, Mariko, Onishi, Chie, Taketani, Takeshi, Purevsuren, Jamiyan, Yamaguchi, Seiji, Conway, Edward M., Pelus, Louis M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021862/
https://www.ncbi.nlm.nih.gov/pubmed/21253548
http://dx.doi.org/10.1155/2011/946936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021862/
https://www.ncbi.nlm.nih.gov/pubmed/21253548
http://dx.doi.org/10.1155/2011/946936

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