In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi

Geldanamycin (GA) is a benzoquinone-containing ansamycin that inhibits heat shock protein 90. GA derivatives are being evaluated as anti-neoplastic agents, but their utility against parasites whose heat shock proteins (Hsps) have homology with human Hsp90 is unknown. The activities of four synthetic...

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Detalles Bibliográficos
Autores principales: Wenkert, David, Ramirez, Bernadette, Shen, Yuehai, Kron, Michael A.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021863/
https://www.ncbi.nlm.nih.gov/pubmed/21253549
http://dx.doi.org/10.1155/2010/716498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021863/
https://www.ncbi.nlm.nih.gov/pubmed/21253549
http://dx.doi.org/10.1155/2010/716498

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