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In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi
Geldanamycin (GA) is a benzoquinone-containing ansamycin that inhibits heat shock protein 90. GA derivatives are being evaluated as anti-neoplastic agents, but their utility against parasites whose heat shock proteins (Hsps) have homology with human Hsp90 is unknown. The activities of four synthetic...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021863/ https://www.ncbi.nlm.nih.gov/pubmed/21253549 http://dx.doi.org/10.1155/2010/716498 |