Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor protein (APP) at alternative sites to produce Aβ and the APP intracellular domain (AICD). Metal ions play an important role in Aβ aggregation and metabolism, thus metal...

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Detalles Bibliográficos
Autores principales: Ho, Michael, Hoke, David E., Chua, Yee Jia, Li, Qiao-Xin, Culvenor, Janetta G., Masters, Colin, White, Anthony R., Evin, Geneviève
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021864/
https://www.ncbi.nlm.nih.gov/pubmed/21253550
http://dx.doi.org/10.4061/2011/950932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021864/
https://www.ncbi.nlm.nih.gov/pubmed/21253550
http://dx.doi.org/10.4061/2011/950932

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