Cargando…

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor protein (APP) at alternative sites to produce Aβ and the APP intracellular domain (AICD). Metal ions play an important role in Aβ aggregation and metabolism, thus metal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ho, Michael, Hoke, David E., Chua, Yee Jia, Li, Qiao-Xin, Culvenor, Janetta G., Masters, Colin, White, Anthony R., Evin, Geneviève
Formato:	Texto
Lenguaje:	English
Publicado:	SAGE-Hindawi Access to Research 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021864/ https://www.ncbi.nlm.nih.gov/pubmed/21253550 http://dx.doi.org/10.4061/2011/950932

Ejemplares similares

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
por: Lessard, Christian B., et al.
Publicado: (2015)

Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation
por: Jin, Chen, et al.
Publicado: (2022)

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase
por: Morishima-Kawashima, Maho
Publicado: (2014)

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites
por: Yan, Yan, et al.
Publicado: (2017)

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
por: Bolduc, David M, et al.
Publicado: (2016)

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
por: Weber, Tobias A., et al.
Publicado: (2021)

Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production
por: Suzuki, Ryota, et al.
Publicado: (2023)

Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease
por: Pluta, Ryszard, et al.
Publicado: (2012)

Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein
por: Do, Hung N., et al.
Publicado: (2023)

Verteporfin is a substrate-selective γ-secretase inhibitor that binds the amyloid precursor protein transmembrane domain
por: Castro, Manuel A., et al.
Publicado: (2022)

Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein
por: Tan, Jiang-Li, et al.
Publicado: (2013)

Correction: Mild Oxidative Stress Induces Redistribution of BACE1 in Non-Apoptotic Conditions and Promotes the Amyloidogenic Processing of Alzheimer’s Disease Amyloid Precursor Protein
por: Tan, Jiang-Li, et al.
Publicado: (2013)

Determination of the Proteolytic Cleavage Sites of the Amyloid Precursor-Like Protein 2 by the Proteases ADAM10, BACE1 and γ-Secretase
por: Hogl, Sebastian, et al.
Publicado: (2011)

Substrate interaction inhibits γ-secretase production of amyloid-β peptides
por: Zhao, Jing, et al.
Publicado: (2020)

A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase
por: Lu, Xiaoli, et al.
Publicado: (2022)

Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase
por: Piao, Yi, et al.
Publicado: (2013)

The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
por: Cupers, Philippe, et al.
Publicado: (2001)

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity
por: Jung, Joo In, et al.
Publicado: (2014)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
por: Lessard, Christian B., et al.
Publicado: (2020)

Secretases Related to Amyloid Precursor Protein Processing
por: Liu, Xiaoling, et al.
Publicado: (2021)

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
por: Uemura, Kengo, et al.
Publicado: (2010)

Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio
por: Xu, Ting-Hai, et al.
Publicado: (2016)

TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage
por: Pardossi-Piquard, Raphaëlle, et al.
Publicado: (2009)

Mechanisms of γ-Secretase Activation and Substrate Processing
por: Bhattarai, Apurba, et al.
Publicado: (2020)

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s disease
por: Serneels, Lutgarde, et al.
Publicado: (2020)

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements
por: Hemming, Matthew L, et al.
Publicado: (2008)

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase
por: Funamoto, Satoru, et al.
Publicado: (2013)

APP substrate ectodomain defines amyloid‐β peptide length by restraining γ‐secretase processivity and facilitating product release
por: Koch, Matthias, et al.
Publicado: (2023)

Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells
por: Chyung, Abraham S.C., et al.
Publicado: (1997)

Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor
por: Gupta-Rossi, Neetu, et al.
Publicado: (2004)

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators
por: Jung, Joo In, et al.
Publicado: (2014)

Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons
por: Annaert, Wim G., et al.
Publicado: (1999)

Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase
por: Lemmin, Thomas, et al.
Publicado: (2014)

γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production
por: Takami, Mako, et al.
Publicado: (2012)

Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues
por: Devkota, Sujan, et al.
Publicado: (2021)

Structural Characterization of the Amyloid Precursor Protein Transmembrane Domain and Its γ-Cleavage Site
por: Itkin, Anna, et al.
Publicado: (2017)

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation†
por: Zhou, Lujia, et al.
Publicado: (2011)

Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein
por: Yang, Ting, et al.
Publicado: (2008)

Acetylcholinesterase blocks cleavage of APP by γ-secretase in 293 cells and mouse brain
por: Niu, Xin, et al.
Publicado: (2012)

Enzyme–substrate interface targeting by imidazole‐based γ‐secretase modulators activates γ‐secretase and stabilizes its interaction with APP
por: Petit, Dieter, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_r8r529lv3d5v24ltu9v66l59db