Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside

Leber's hereditary optic neuropathy (LHON) is a maternally transmitted disorder caused by point mutations in mitochondrial DNA (mtDNA). Most cases are due to mutations in genes encoding subunits of the NADH-ubiquinone oxidoreductase that is Complex I of the electron transport chain (ETC). These...

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Detalles Bibliográficos
Autores principales: Koilkonda, Rajeshwari D., Guy, John
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021870/
https://www.ncbi.nlm.nih.gov/pubmed/21253496
http://dx.doi.org/10.1155/2011/179412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021870/
https://www.ncbi.nlm.nih.gov/pubmed/21253496
http://dx.doi.org/10.1155/2011/179412

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