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Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside
Leber's hereditary optic neuropathy (LHON) is a maternally transmitted disorder caused by point mutations in mitochondrial DNA (mtDNA). Most cases are due to mutations in genes encoding subunits of the NADH-ubiquinone oxidoreductase that is Complex I of the electron transport chain (ETC). These...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Hindawi Publishing Corporation
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021870/ https://www.ncbi.nlm.nih.gov/pubmed/21253496 http://dx.doi.org/10.1155/2011/179412 |