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Identification of Distinctive Patterns of USP19-Mediated Growth Regulation in Normal and Malignant Cells

We previously reported that the USP19 deubiquitinating enzyme positively regulates proliferation in fibroblasts by stabilizing KPC1, a ubiquitin ligase for p27(Kip1). To explore whether this role of USP19 extends to other cellular systems, we tested the effects of silencing of USP19 in several human...

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Detalles Bibliográficos
Autores principales: Lu, Yu, Bedard, Nathalie, Chevalier, Simone, Wing, Simon S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022023/
https://www.ncbi.nlm.nih.gov/pubmed/21264218
http://dx.doi.org/10.1371/journal.pone.0015936