A Single Acidic Residue Can Guide Binding Site Selection but Does Not Govern QacR Cationic-Drug Affinity

Structures of the multidrug-binding repressor protein QacR with monovalent and bivalent cationic drugs revealed that the carboxylate side-chains of E90 and E120 were proximal to the positively charged nitrogens of the ligands ethidium, malachite green and rhodamine 6G, and therefore may contribute t...

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Detalles Bibliográficos
Autores principales: Peters, Kate M., Brooks, Benjamin E., Schumacher, Maria A., Skurray, Ronald A., Brennan, Richard G., Brown, Melissa H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022030/
https://www.ncbi.nlm.nih.gov/pubmed/21264225
http://dx.doi.org/10.1371/journal.pone.0015974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022030/
https://www.ncbi.nlm.nih.gov/pubmed/21264225
http://dx.doi.org/10.1371/journal.pone.0015974

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