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Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse

The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS...

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Detalles Bibliográficos
Autores principales: Longhini, Ana Leda F, von Glehn, Felipe, Brandão, Carlos Otávio, de Paula, Rosemeire FO, Pradella, Fernando, Moraes, Adriel S, Farias, Alessandro S, Oliveira, Elaine C, Quispe-Cabanillas, Juan G, Abreu, Cassiana Horta, Damasceno, Alfredo, Damasceno, Benito P, Balashov, Konstantin E, Santos, Leonilda MB
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022734/
https://www.ncbi.nlm.nih.gov/pubmed/21214939
http://dx.doi.org/10.1186/1742-2094-8-2
Descripción
Sumario:The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS). In the present study, we determinate pDCs levels by flow cytometry in Cerebrospinal Fluid (CSF) and Peripheral Blood from MS patients in relapsing and in remitting phases of the disease, comparing with other non-inflammatory diseases (OND). We provide evidence that MS patients in relapse without any treatment have a significantly (p < 0.01) higher percentage of pDCs in CSF than do patients in remission or those with OND. No change in the percentage of pDCs was observed in the peripheral blood of any of these patients. The increase of pDCs in central nervous system during relapse may be explained either by a virus infection or a down regulatory process.