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Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse

The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS...

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Autores principales: Longhini, Ana Leda F, von Glehn, Felipe, Brandão, Carlos Otávio, de Paula, Rosemeire FO, Pradella, Fernando, Moraes, Adriel S, Farias, Alessandro S, Oliveira, Elaine C, Quispe-Cabanillas, Juan G, Abreu, Cassiana Horta, Damasceno, Alfredo, Damasceno, Benito P, Balashov, Konstantin E, Santos, Leonilda MB
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022734/
https://www.ncbi.nlm.nih.gov/pubmed/21214939
http://dx.doi.org/10.1186/1742-2094-8-2
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author Longhini, Ana Leda F
von Glehn, Felipe
Brandão, Carlos Otávio
de Paula, Rosemeire FO
Pradella, Fernando
Moraes, Adriel S
Farias, Alessandro S
Oliveira, Elaine C
Quispe-Cabanillas, Juan G
Abreu, Cassiana Horta
Damasceno, Alfredo
Damasceno, Benito P
Balashov, Konstantin E
Santos, Leonilda MB
author_facet Longhini, Ana Leda F
von Glehn, Felipe
Brandão, Carlos Otávio
de Paula, Rosemeire FO
Pradella, Fernando
Moraes, Adriel S
Farias, Alessandro S
Oliveira, Elaine C
Quispe-Cabanillas, Juan G
Abreu, Cassiana Horta
Damasceno, Alfredo
Damasceno, Benito P
Balashov, Konstantin E
Santos, Leonilda MB
author_sort Longhini, Ana Leda F
collection PubMed
description The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS). In the present study, we determinate pDCs levels by flow cytometry in Cerebrospinal Fluid (CSF) and Peripheral Blood from MS patients in relapsing and in remitting phases of the disease, comparing with other non-inflammatory diseases (OND). We provide evidence that MS patients in relapse without any treatment have a significantly (p < 0.01) higher percentage of pDCs in CSF than do patients in remission or those with OND. No change in the percentage of pDCs was observed in the peripheral blood of any of these patients. The increase of pDCs in central nervous system during relapse may be explained either by a virus infection or a down regulatory process.
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spelling pubmed-30227342011-01-19 Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse Longhini, Ana Leda F von Glehn, Felipe Brandão, Carlos Otávio de Paula, Rosemeire FO Pradella, Fernando Moraes, Adriel S Farias, Alessandro S Oliveira, Elaine C Quispe-Cabanillas, Juan G Abreu, Cassiana Horta Damasceno, Alfredo Damasceno, Benito P Balashov, Konstantin E Santos, Leonilda MB J Neuroinflammation Short Report The plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS). In the present study, we determinate pDCs levels by flow cytometry in Cerebrospinal Fluid (CSF) and Peripheral Blood from MS patients in relapsing and in remitting phases of the disease, comparing with other non-inflammatory diseases (OND). We provide evidence that MS patients in relapse without any treatment have a significantly (p < 0.01) higher percentage of pDCs in CSF than do patients in remission or those with OND. No change in the percentage of pDCs was observed in the peripheral blood of any of these patients. The increase of pDCs in central nervous system during relapse may be explained either by a virus infection or a down regulatory process. BioMed Central 2011-01-07 /pmc/articles/PMC3022734/ /pubmed/21214939 http://dx.doi.org/10.1186/1742-2094-8-2 Text en Copyright ©2011 Longhini et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<url>http://creativecommons.org/licenses/by/2.0</url>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Longhini, Ana Leda F
von Glehn, Felipe
Brandão, Carlos Otávio
de Paula, Rosemeire FO
Pradella, Fernando
Moraes, Adriel S
Farias, Alessandro S
Oliveira, Elaine C
Quispe-Cabanillas, Juan G
Abreu, Cassiana Horta
Damasceno, Alfredo
Damasceno, Benito P
Balashov, Konstantin E
Santos, Leonilda MB
Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse
title Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse
title_full Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse
title_fullStr Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse
title_full_unstemmed Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse
title_short Plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse
title_sort plasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapse
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022734/
https://www.ncbi.nlm.nih.gov/pubmed/21214939
http://dx.doi.org/10.1186/1742-2094-8-2
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