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Point Mutations in Aβ Result in the Formation of Distinct Polymorphic Aggregates in the Presence of Lipid Bilayers

A hallmark of Alzheimer's disease (AD) is the rearrangement of the β-amyloid (Aβ) peptide to a non-native conformation that promotes the formation of toxic, nanoscale aggregates. Recent studies have pointed to the role of sample preparation in creating polymorphic fibrillar species. One of many...

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Detalles Bibliográficos
Autores principales: Pifer, Phillip M., Yates, Elizabeth A., Legleiter, Justin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022758/
https://www.ncbi.nlm.nih.gov/pubmed/21267410
http://dx.doi.org/10.1371/journal.pone.0016248