(R)-[(11)C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

BACKGROUND: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection o...

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Detalles Bibliográficos
Autores principales: Syvänen, Stina, Luurtsema, Gert, Molthoff, Carla FM, Windhorst, Albert D, Huisman, Marc C, Lammertsma, Adriaan A, Voskuyl, Rob A, de Lange, Elizabeth C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022839/
https://www.ncbi.nlm.nih.gov/pubmed/21199574
http://dx.doi.org/10.1186/1471-2342-11-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022839/
https://www.ncbi.nlm.nih.gov/pubmed/21199574
http://dx.doi.org/10.1186/1471-2342-11-1

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