Cargando…

(R)-[(11)C]Verapamil PET studies to assess changes in P-glycoprotein expression and functionality in rat blood-brain barrier after exposure to kainate-induced status epilepticus

BACKGROUND: Increased functionality of efflux transporters at the blood-brain barrier may contribute to decreased drug concentrations at the target site in CNS diseases like epilepsy. In the rat, pharmacoresistant epilepsy can be mimicked by inducing status epilepticus by intraperitoneal injection o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Syvänen, Stina, Luurtsema, Gert, Molthoff, Carla FM, Windhorst, Albert D, Huisman, Marc C, Lammertsma, Adriaan A, Voskuyl, Rob A, de Lange, Elizabeth C
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022839/ https://www.ncbi.nlm.nih.gov/pubmed/21199574 http://dx.doi.org/10.1186/1471-2342-11-1

Ejemplares similares

Synthesis and preliminary preclinical evaluation of fluorine-18 labelled isatin-4-(4-methoxyphenyl)-3-thiosemicarbazone ([(18)F]4FIMPTC) as a novel PET tracer of P-glycoprotein expression
por: Verbeek, Joost, et al.
Publicado: (2018)

Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate
por: Syvänen, Stina, et al.
Publicado: (2012)

[(11)C]Flumazenil brain uptake is influenced by the blood-brain barrier efflux transporter P-glycoprotein
por: Froklage, Femke E, et al.
Publicado: (2012)

Synthesis and Evaluation of New Fluorine-18 Labeled Verapamil Analogs To Investigate the Function of P-Glycoprotein in the Blood–Brain Barrier
por: Raaphorst, Renske M., et al.
Publicado: (2017)

Pharmacokinetic modeling of P-glycoprotein function at the rat and human blood–brain barriers studied with (R)-[(11)C]verapamil positron emission tomography
por: Müllauer, Julia, et al.
Publicado: (2012)

Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging
por: Raaphorst, Renske M., et al.
Publicado: (2017)

[(11)C]phenytoin revisited: synthesis by [(11)C]CO carbonylation and first evaluation as a P-gp tracer in rats
por: Verbeek, Joost, et al.
Publicado: (2012)

Reproducibility of quantitative (R)-[(11)C]verapamil studies
por: van Assema, Daniëlle ME, et al.
Publicado: (2012)

Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis
por: Gent, Yoony YJ, et al.
Publicado: (2014)

Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus
por: Levine, Amber T., et al.
Publicado: (2020)

Pharmacokinetic Modeling of (R)-[(11)C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates
por: García-Varela, Lara, et al.
Publicado: (2020)

Status Epilepticus: Behavioral and Electroencephalography Seizure Correlates in Kainate Experimental Models
por: Sharma, Shaunik, et al.
Publicado: (2018)

Evaluation of the novel folate receptor ligand [(18)F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis
por: Gent, Yoony YJ, et al.
Publicado: (2013)

Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study
por: Folkersma, Hedy, et al.
Publicado: (2011)

Test-retest variability of quantitative [(11)C]PIB studies in Alzheimer’s disease
por: Tolboom, Nelleke, et al.
Publicado: (2009)

Imaging and Methotrexate Response Monitoring of Systemic Inflammation in Arthritic Rats Employing the Macrophage PET Tracer [(18)F]Fluoro-PEG-Folate
por: Chandrupatla, Durga M. S. H., et al.
Publicado: (2018)

[(11)C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors
por: Buiter, Hans JC, et al.
Publicado: (2013)

Radiosynthesis and preclinical evaluation of [(11)C]prucalopride as a potential agonist PET ligand for the 5-HT(4) receptor
por: Buiter, Hans JC, et al.
Publicado: (2013)

Quantification of P-glycoprotein function at the human blood-brain barrier using [(18)F]MC225 and PET
por: Mossel, Pascalle, et al.
Publicado: (2023)

Reproducible Analysis of Rat Brain PET Studies Using an Additional [(18)F]NaF Scan and an MR-Based ROI Template
por: Buiter, Hans J. C., et al.
Publicado: (2012)

F8-IL10: A New Potential Antirheumatic Drug Evaluated by a PET-Guided Translational Approach
por: Bruijnen, Stefan T.G., et al.
Publicado: (2018)

Evaluation of P-glycoprotein function at the blood–brain barrier using [(18)F]MC225-PET
por: Mossel, Pascalle, et al.
Publicado: (2021)

Impact of New Scatter Correction Strategies on High-Resolution Research Tomograph Brain PET Studies
por: Mansor, Syahir, et al.
Publicado: (2016)

Head-to-head comparison of (R)-[(11)C]verapamil and [(18)F]MC225 in non-human primates, tracers for measuring P-glycoprotein function
por: García-Varela, Lara, et al.
Publicado: (2021)

Verapamil and Rifampin Effect on P-Glycoprotein Expression in Hepatocellular Carcinoma
por: Jalali, Amir, et al.
Publicado: (2014)

Monitoring Response to Radiotherapy in Human Squamous Cell Cancer Bearing Nude Mice: Comparison of 2′-deoxy-2′-[(18)F]fluoro-d-glucose (FDG) and 3′-[(18)F]fluoro-3′-deoxythymidine (FLT)
por: Molthoff, Carla F. M., et al.
Publicado: (2007)

Approaching complete inhibition of P-glycoprotein at the human blood–brain barrier: an (R)-[(11)C]verapamil PET study
por: Bauer, Martin, et al.
Publicado: (2015)

Engineered antibodies: new possibilities for brain PET?
por: Sehlin, Dag, et al.
Publicado: (2019)

Trafficking of Kainate Receptors
por: Pahl, Steffen, et al.
Publicado: (2014)

Evaluation of Tracer Kinetic Models for Analysis of [(18)F]FDDNP Studies
por: Yaqub, Maqsood, et al.
Publicado: (2009)

Diabetic cardiomyopathy in Zucker diabetic fatty rats: the forgotten right ventricle
por: van den Brom, Charissa E, et al.
Publicado: (2010)

Non-invasive kinetic modelling approaches for quantitative analysis of brain PET studies
por: van der Weijden, Chris W. J., et al.
Publicado: (2023)

P-Glycoprotein Function at the Blood–Brain Barrier: Effects of Age and Gender
por: van Assema, Daniëlle M. E., et al.
Publicado: (2012)

Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography
por: van den Brom, Charissa E, et al.
Publicado: (2009)

Day-to-Day Test–Retest Variability of CBF, CMRO(2), and OEF Measurements Using Dynamic (15)O PET Studies
por: Bremmer, Jochem P., et al.
Publicado: (2010)

Dose-response assessment of tariquidar for inhibition of P-glycoprotein at the human blood-brain barrier using (R)-[(11)C]verapamil PET
por: Bauer, Martin, et al.
Publicado: (2010)

Verapamil as treatment for refractory status epilepticus secondary to PRES syndrome on a SARS-Cov-2 infected patient
por: Gómez-Enjuto, Sara, et al.
Publicado: (2020)

Model selection criteria for dynamic brain PET studies
por: Golla, Sandeep S. V., et al.
Publicado: (2017)

Sustained Macrophage Infiltration upon Multiple Intra-Articular Injections: An Improved Rat Model of Rheumatoid Arthritis for PET Guided Therapy Evaluation
por: Chandrupatla, Durga M. S. H., et al.
Publicado: (2015)

Guidelines to PET measurements of the target occupancy in the brain for drug development
por: Takano, Akihiro, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rulaaou1lg8724308f776tn5a8