A Single Amino Acid Substitution Makes WNK4 Susceptible to SB 203580 and SB 202190

Regulation of the SLC12 family of membrane transporters including NCCT involves a scaffold of interacting proteins including the STE 20 kinase SPAK and the WNK kinases, WNK 1 and WNK 4, which are mutated in the hypertensive syndrome of pseudohypoaldosteronism type 2 (PHAII). WNK4 regulates NCCT by a...

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Detalles Bibliográficos
Autores principales: Glover, Mark, Sweeney, Connor, Davis, Bill, O’Shaughnessy, Kevin M
Formato: Texto
Lenguaje:English
Publicado: Bentham Open 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023092/
https://www.ncbi.nlm.nih.gov/pubmed/21249167
http://dx.doi.org/10.2174/1874104501004010057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023092/
https://www.ncbi.nlm.nih.gov/pubmed/21249167
http://dx.doi.org/10.2174/1874104501004010057

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