A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC

Self-reactive T cells that escape elimination in the thymus can cause autoimmune pathology, and it is therefore important to understand the structural mechanisms of self-antigen recognition. We report the crystal structure of a T cell receptor (TCR) from a patient with relapsing-remitting multiple s...

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Detalles Bibliográficos
Autores principales: Sethi, Dhruv K., Schubert, David A., Anders, Anne-Kathrin, Heroux, Annie, Bonsor, Daniel A., Thomas, Chantz P., Sundberg, Eric J., Pyrdol, Jason, Wucherpfennig, Kai W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023130/
https://www.ncbi.nlm.nih.gov/pubmed/21199956
http://dx.doi.org/10.1084/jem.20100725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023130/
https://www.ncbi.nlm.nih.gov/pubmed/21199956
http://dx.doi.org/10.1084/jem.20100725

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