CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10–driven MARCH1-mediated ubiquitination and degradation

Effective vaccine adjuvants must induce expression of major histocompatability (MHC) class II proteins and the costimulatory molecule CD86 on dendritic cells (DCs). However, some adjuvants elicit production of cytokines resulting in adverse inflammatory consequences. Development of agents that selec...

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Detalles Bibliográficos
Autores principales: Tze, Lina E., Horikawa, Keisuke, Domaschenz, Heather, Howard, Debbie R., Roots, Carla M., Rigby, Robert J., Way, David A., Ohmura-Hoshino, Mari, Ishido, Satoshi, Andoniou, Christopher E., Degli-Esposti, Mariapia A., Goodnow, Christopher C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023131/
https://www.ncbi.nlm.nih.gov/pubmed/21220452
http://dx.doi.org/10.1084/jem.20092203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023131/
https://www.ncbi.nlm.nih.gov/pubmed/21220452
http://dx.doi.org/10.1084/jem.20092203

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