Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages

Palmitic acid (PA) upregulates oxidized LDL receptor-1 (LOX-1), a scavenger receptor responsible for uptake of oxidized LDL (oxLDL), and enhances oxLDL uptake in macrophages. However, the precise underlying mechanism remains to be elucidated. PA is known to induce endoplasmic reticulum (ER) stress i...

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Detalles Bibliográficos
Autores principales: Ishiyama, Junichi, Taguchi, Ryoko, Akasaka, Yunike, Shibata, Saiko, Ito, Minoru, Nagasawa, Michiaki, Murakami, Koji
Formato: Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023550/
https://www.ncbi.nlm.nih.gov/pubmed/21078775
http://dx.doi.org/10.1194/jlr.M007104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023550/
https://www.ncbi.nlm.nih.gov/pubmed/21078775
http://dx.doi.org/10.1194/jlr.M007104

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