Chronic CSE Treatment Induces the Growth of Normal Oral Keratinocytes via PDK2 Upregulation, Increased Glycolysis and HIF1α Stabilization

BACKGROUND: Exposure to cigarette smoke is a major risk factor for head and neck squamous cell carcinoma (HNSCC). We have previously established a chronic cigarette smoke extract (CSE)-treated human oral normal keratinocyte model, demonstrating an elevated frequency of mitochondrial mutations in CSE...

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Detalles Bibliográficos
Autores principales: Sun, Wenyue, Chang, Steven S., Fu, Yumei, Liu, Yan, Califano, Joseph A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023770/
https://www.ncbi.nlm.nih.gov/pubmed/21283817
http://dx.doi.org/10.1371/journal.pone.0016207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023770/
https://www.ncbi.nlm.nih.gov/pubmed/21283817
http://dx.doi.org/10.1371/journal.pone.0016207

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