Lkb1 and Pten Synergise to Suppress mTOR-Mediated Tumorigenesis and Epithelial-Mesenchymal Transition in the Mouse Bladder

The AKT/PI3K/mTOR pathway is frequently altered in a range of human tumours, including bladder cancer. Here we report the phenotype of mice characterised by deletion of two key players in mTOR regulation, Pten and Lkb1, in a range of tissues including the mouse urothelium. Despite widespread recombi...

Descripción completa

Detalles Bibliográficos
Autores principales: Shorning, Boris Y., Griffiths, David, Clarke, Alan R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023771/
https://www.ncbi.nlm.nih.gov/pubmed/21283818
http://dx.doi.org/10.1371/journal.pone.0016209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023771/
https://www.ncbi.nlm.nih.gov/pubmed/21283818
http://dx.doi.org/10.1371/journal.pone.0016209

Ejemplares similares