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A redox switch in angiotensinogen modulates angiotensin release

Blood pressure is critically controlled by angiotensins1, vasopressor peptides specifically released by the enzyme renin from the tail of angiotensinogen, a non-inhibitory member of the serpin family of protease inhibitors2,3. Although angiotensinogen has long been regarded as a passive substrate, t...

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Detalles Bibliográficos
Autores principales: Zhou, Aiwu, Carrell, Robin W, Murphy, Michael P, Wei, Zhenquan, Yan, Yahui, Stanley, Peter L.D., Stein, Penelope E, Pipkin, Fiona Broughton, Read, Randy J
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024006/
https://www.ncbi.nlm.nih.gov/pubmed/20927107
http://dx.doi.org/10.1038/nature09505