Impact of early fructose intake on metabolic profile and aerobic capacity of rats

BACKGROUND: Metabolic syndrome is a disease that today affects millions of people around the world. Therefore, it is of great interest to implement more effective procedures for preventing and treating this disease. In search of a suitable experimental model to study the role of exercise in preventi...

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Autores principales: Ghezzi, Ana C, Cambri, Lucieli T, Ribeiro, Carla, Botezelli, José D, Mello, Maria AR
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024237/
https://www.ncbi.nlm.nih.gov/pubmed/21223589
http://dx.doi.org/10.1186/1476-511X-10-3
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author Ghezzi, Ana C
Cambri, Lucieli T
Ribeiro, Carla
Botezelli, José D
Mello, Maria AR
author_facet Ghezzi, Ana C
Cambri, Lucieli T
Ribeiro, Carla
Botezelli, José D
Mello, Maria AR
author_sort Ghezzi, Ana C
collection PubMed
description BACKGROUND: Metabolic syndrome is a disease that today affects millions of people around the world. Therefore, it is of great interest to implement more effective procedures for preventing and treating this disease. In search of a suitable experimental model to study the role of exercise in prevention and treatment of metabolic syndrome, this study examined the metabolic profile and the aerobic capacity of rats kept early in life on a fructose-rich diet, a substrate that has been associated with metabolic syndrome. METHODS: We used adult female Wistar rats fed during pregnancy and lactation with two diets: balanced or fructose-rich 60%. During breastfeeding, the pups were distributed in small (4/mother) or adequate (8/mother) litters. At 90 days of age, they were analyzed with respect to: glucose tolerance, peripheral insulin sensitivity, aerobic capacity and serum glucose, insulin, triglycerides, total cholesterol, LDL cholesterol and HDL cholesterol concentrations as well as measures of glycogen synthesis and glucose oxidation by the soleus muscle. RESULTS: It was found that the fructose rich diet led the animals to insulin resistance. The fructose fed rats kept in small litters also showed dyslipidemia, with increased serum concentrations of total cholesterol and triglycerides. CONCLUSION: Neither the aerobic capacity nor the glucose oxidation rates by the skeletal muscle were altered by fructose-rich diet, indicating that the animal model evaluated is potentially interesting for the study of the role of exercise in metabolic syndrome.
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spelling pubmed-30242372011-01-21 Impact of early fructose intake on metabolic profile and aerobic capacity of rats Ghezzi, Ana C Cambri, Lucieli T Ribeiro, Carla Botezelli, José D Mello, Maria AR Lipids Health Dis Research BACKGROUND: Metabolic syndrome is a disease that today affects millions of people around the world. Therefore, it is of great interest to implement more effective procedures for preventing and treating this disease. In search of a suitable experimental model to study the role of exercise in prevention and treatment of metabolic syndrome, this study examined the metabolic profile and the aerobic capacity of rats kept early in life on a fructose-rich diet, a substrate that has been associated with metabolic syndrome. METHODS: We used adult female Wistar rats fed during pregnancy and lactation with two diets: balanced or fructose-rich 60%. During breastfeeding, the pups were distributed in small (4/mother) or adequate (8/mother) litters. At 90 days of age, they were analyzed with respect to: glucose tolerance, peripheral insulin sensitivity, aerobic capacity and serum glucose, insulin, triglycerides, total cholesterol, LDL cholesterol and HDL cholesterol concentrations as well as measures of glycogen synthesis and glucose oxidation by the soleus muscle. RESULTS: It was found that the fructose rich diet led the animals to insulin resistance. The fructose fed rats kept in small litters also showed dyslipidemia, with increased serum concentrations of total cholesterol and triglycerides. CONCLUSION: Neither the aerobic capacity nor the glucose oxidation rates by the skeletal muscle were altered by fructose-rich diet, indicating that the animal model evaluated is potentially interesting for the study of the role of exercise in metabolic syndrome. BioMed Central 2011-01-11 /pmc/articles/PMC3024237/ /pubmed/21223589 http://dx.doi.org/10.1186/1476-511X-10-3 Text en Copyright ©2011 Ghezzi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Ghezzi, Ana C
Cambri, Lucieli T
Ribeiro, Carla
Botezelli, José D
Mello, Maria AR
Impact of early fructose intake on metabolic profile and aerobic capacity of rats
title Impact of early fructose intake on metabolic profile and aerobic capacity of rats
title_full Impact of early fructose intake on metabolic profile and aerobic capacity of rats
title_fullStr Impact of early fructose intake on metabolic profile and aerobic capacity of rats
title_full_unstemmed Impact of early fructose intake on metabolic profile and aerobic capacity of rats
title_short Impact of early fructose intake on metabolic profile and aerobic capacity of rats
title_sort impact of early fructose intake on metabolic profile and aerobic capacity of rats
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024237/
https://www.ncbi.nlm.nih.gov/pubmed/21223589
http://dx.doi.org/10.1186/1476-511X-10-3
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