Constitutive Activation of the Thyroid-Stimulating Hormone Receptor (TSHR) by Mutating Ile(691) in the Cytoplasmic Tail Segment

BACKGROUND: Autosomal dominant non-autoimmune hyperthyroidism (ADNAH) is a rare genetic disorder of the endocrine system. Molecular genetic studies in ADNAH have revealed heterozygous germline mutations in the TSHR. To data, mutations leading to an increase in the constitutive activation of the TSHR...

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Detalles Bibliográficos
Autores principales: Liu, Zheng, Fan, Feiyue, Xiao, Xiangjun, Sun, Yuanming
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025015/
https://www.ncbi.nlm.nih.gov/pubmed/21283701
http://dx.doi.org/10.1371/journal.pone.0016335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025015/
https://www.ncbi.nlm.nih.gov/pubmed/21283701
http://dx.doi.org/10.1371/journal.pone.0016335

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