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Constitutive Activation of the Thyroid-Stimulating Hormone Receptor (TSHR) by Mutating Ile(691) in the Cytoplasmic Tail Segment
BACKGROUND: Autosomal dominant non-autoimmune hyperthyroidism (ADNAH) is a rare genetic disorder of the endocrine system. Molecular genetic studies in ADNAH have revealed heterozygous germline mutations in the TSHR. To data, mutations leading to an increase in the constitutive activation of the TSHR...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025015/ https://www.ncbi.nlm.nih.gov/pubmed/21283701 http://dx.doi.org/10.1371/journal.pone.0016335 |