Long Tract of Untranslated CAG Repeats Is Deleterious in Transgenic Mice

The most frequent trinucleotide repeat found in human disorders is the CAG sequence. Expansion of CAG repeats is mostly found in coding regions and is thought to cause diseases through a protein mechanism. Recently, expanded CAG repeats were shown to induce toxicity at the RNA level in Drosophila an...

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Detalles Bibliográficos
Autores principales: Hsu, Ren-Jun, Hsiao, Kuang-Ming, Lin, Min-Jon, Li, Chui-Yen, Wang, Li-Chun, Chen, Luen-Kui, Pan, Huichin
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025035/
https://www.ncbi.nlm.nih.gov/pubmed/21283659
http://dx.doi.org/10.1371/journal.pone.0016417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025035/
https://www.ncbi.nlm.nih.gov/pubmed/21283659
http://dx.doi.org/10.1371/journal.pone.0016417

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