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Long Tract of Untranslated CAG Repeats Is Deleterious in Transgenic Mice
The most frequent trinucleotide repeat found in human disorders is the CAG sequence. Expansion of CAG repeats is mostly found in coding regions and is thought to cause diseases through a protein mechanism. Recently, expanded CAG repeats were shown to induce toxicity at the RNA level in Drosophila an...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025035/ https://www.ncbi.nlm.nih.gov/pubmed/21283659 http://dx.doi.org/10.1371/journal.pone.0016417 |