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Nanog Overcomes Reprogramming Barriers and Induces Pluripotency in Minimal Conditions
Induced pluripotency requires the expression of defined factors and culture conditions that support the self-renewal of embryonic stem (ES) cells [1]. Small molecule inhibition of MAP kinase (MEK) and glycogen synthase kinase 3 (GSK3) with LIF (2i/LIF) provides an optimal culture environment for mou...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025321/ https://www.ncbi.nlm.nih.gov/pubmed/21194951 http://dx.doi.org/10.1016/j.cub.2010.11.074 |