Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

A resazurin-based cell viability assay was developed for phenotypic screening of the LOPAC 1280 ‘library of pharmacologically active compounds’ against bloodstream forms of Trypanosoma brucei in vitro identifying 33 compounds with EC(50) values <1 μM. Counter-screening vs. normal diploid human fi...

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Detalles Bibliográficos
Autores principales: Jones, Deuan C., Hallyburton, Irene, Stojanovski, Laste, Read, Kevin D., Frearson, Julie A., Fairlamb, Alan H.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025325/
https://www.ncbi.nlm.nih.gov/pubmed/20696141
http://dx.doi.org/10.1016/j.bcp.2010.07.038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025325/
https://www.ncbi.nlm.nih.gov/pubmed/20696141
http://dx.doi.org/10.1016/j.bcp.2010.07.038

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