Endothelial cell talin1 is essential for embryonic angiogenesis

Using Tln1(fl/fl);CreER mice, we show that tamoxifen-induced inactivation of the talin1 gene throughout the embryo produces an angiogenesis phenotype that is restricted to newly forming blood vessels. The phenotype has a rapid onset in early embryos, resulting in vessel defects by 48 h and death of...

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Detalles Bibliográficos
Autores principales: Monkley, Susan J., Kostourou, Vassiliki, Spence, Lorraine, Petrich, Brian, Coleman, Stacey, Ginsberg, Mark H., Pritchard, Catrin A., Critchley, David R.
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025397/
https://www.ncbi.nlm.nih.gov/pubmed/21081121
http://dx.doi.org/10.1016/j.ydbio.2010.11.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025397/
https://www.ncbi.nlm.nih.gov/pubmed/21081121
http://dx.doi.org/10.1016/j.ydbio.2010.11.010

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