HIV-1 RT-dependent DNAzyme expression inhibits HIV-1 replication without the emergence of escape viruses

DNAzymes are easier to prepare and less sensitive to chemical and enzymatic degradation than ribozymes; however, a DNA enzyme expression system has not yet been developed. In this study, we exploited the mechanism of HIV-1 reverse transcription (RT) in a DNA enzyme expression system. We constructed...

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Detalles Bibliográficos
Autores principales: Sugiyama, Ryuichi, Hayafune, Masaaki, Habu, Yuichiro, Yamamoto, Norio, Takaku, Hiroshi
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025543/
https://www.ncbi.nlm.nih.gov/pubmed/20833635
http://dx.doi.org/10.1093/nar/gkq794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025543/
https://www.ncbi.nlm.nih.gov/pubmed/20833635
http://dx.doi.org/10.1093/nar/gkq794

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