Cargando…

On the molecular basis of uracil recognition in DNA: comparative study of T-A versus U-A structure, dynamics and open base pair kinetics

Uracil (U) can be found in DNA as a mismatch paired either to adenine (A) or to guanine (G). Removal of U from DNA is performed by a class of enzymes known as uracil–DNA–glycosylases (UDG). Recent studies suggest that recognition of U–A and U–G mismatches by UDG takes place via an extra-helical mech...

Descripción completa

Detalles Bibliográficos
Autores principales: Fadda, Elisa, Pomès, Régis
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025553/
https://www.ncbi.nlm.nih.gov/pubmed/20876689
http://dx.doi.org/10.1093/nar/gkq812