6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death

BACKGROUND: Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN), resulting in tremor, rigidity, and bradykinesia. Although the etiology is unknown, insight into the disease process comes from the dopamine (DA) derivative, 6-hydrox...

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Detalles Bibliográficos
Autores principales: Bernstein, Alison I, Garrison, Sean P, Zambetti, Gerard P, O'Malley, Karen L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025875/
https://www.ncbi.nlm.nih.gov/pubmed/21211034
http://dx.doi.org/10.1186/1750-1326-6-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025875/
https://www.ncbi.nlm.nih.gov/pubmed/21211034
http://dx.doi.org/10.1186/1750-1326-6-2

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