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6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
BACKGROUND: Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons in the substantia nigra (SN), resulting in tremor, rigidity, and bradykinesia. Although the etiology is unknown, insight into the disease process comes from the dopamine (DA) derivative, 6-hydrox...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025875/ https://www.ncbi.nlm.nih.gov/pubmed/21211034 http://dx.doi.org/10.1186/1750-1326-6-2 |