Crystal Structure of the Pyrazinamidase of Mycobacterium tuberculosis: Insights into Natural and Acquired Resistance to Pyrazinamide

Pyrazinamidase (PncA) activates the first-line antituberculous drug pyrazinamide into pyrazinoic acid. The crystal structure of the Mycobacterium tuberculosis PncA protein has been determined, showing significant differences in the substrate binding cavity when compared to the pyrazinamidases from P...

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Detalles Bibliográficos
Autores principales: Petrella, Stéphanie, Gelus-Ziental, Nathalie, Maudry, Arnaud, Laurans, Caroline, Boudjelloul, Rachid, Sougakoff, Wladimir
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025910/
https://www.ncbi.nlm.nih.gov/pubmed/21283666
http://dx.doi.org/10.1371/journal.pone.0015785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025910/
https://www.ncbi.nlm.nih.gov/pubmed/21283666
http://dx.doi.org/10.1371/journal.pone.0015785

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