Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells

BACKGROUND: The cyclin-dependent kinase (CDK) inhibitor p27(Kip1 )is downregulated in a majority of human cancers due to ectopic proteolysis by the ubiquitin-proteasome pathway. The expression of p27 is subject to multiple mechanisms of control involving several transcription factors, kinase pathway...

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Detalles Bibliográficos
Autores principales: Rico-Bautista, Elizabeth, Yang, Chih-Cheng, Lu, Lifang, Roth, Gregory P, Wolf, Dieter A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025922/
https://www.ncbi.nlm.nih.gov/pubmed/21182779
http://dx.doi.org/10.1186/1741-7007-8-153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025922/
https://www.ncbi.nlm.nih.gov/pubmed/21182779
http://dx.doi.org/10.1186/1741-7007-8-153

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