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Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells

BACKGROUND: The cyclin-dependent kinase (CDK) inhibitor p27(Kip1 )is downregulated in a majority of human cancers due to ectopic proteolysis by the ubiquitin-proteasome pathway. The expression of p27 is subject to multiple mechanisms of control involving several transcription factors, kinase pathway...

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Detalles Bibliográficos
Autores principales:	Rico-Bautista, Elizabeth, Yang, Chih-Cheng, Lu, Lifang, Roth, Gregory P, Wolf, Dieter A
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025922/ https://www.ncbi.nlm.nih.gov/pubmed/21182779 http://dx.doi.org/10.1186/1741-7007-8-153

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