Characterization of ERK Docking Domain Inhibitors that Induce Apoptosis by Targeting Rsk-1 and Caspase-9

BACKGROUND: The extracellular signal-regulated kinase-1 and 2 (ERK1/2) proteins play an important role in cancer cell proliferation and survival. ERK1/2 proteins also are important for normal cell functions. Thus, anti-cancer therapies that block all ERK1/2 signaling may result in undesirable toxici...

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Detalles Bibliográficos
Autores principales: Boston, Sarice R, Deshmukh, Rahul, Strome, Scott, Priyakumar, U Deva, MacKerell, Alexander D, Shapiro, Paul
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025971/
https://www.ncbi.nlm.nih.gov/pubmed/21219631
http://dx.doi.org/10.1186/1471-2407-11-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025971/
https://www.ncbi.nlm.nih.gov/pubmed/21219631
http://dx.doi.org/10.1186/1471-2407-11-7

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