LZAP Inhibits p38 MAPK (p38) Phosphorylation and Activity by Facilitating p38 Association with the Wild-Type p53 Induced Phosphatase 1 (WIP1)

LZAP (Cdk5rap3, C53) is a putative tumor suppressor that inhibits RelA, Chk1 and Chk2 and activates p53. LZAP is lost in a portion of human head and neck squamous cell carcinoma and experimental loss of LZAP expression is associated with enhanced invasion, xenograft tumor growth and angiogenesis. p3...

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Detalles Bibliográficos
Autores principales: An, Hanbing, Lu, Xinyuan, Liu, Dan, Yarbrough, Wendell G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026010/
https://www.ncbi.nlm.nih.gov/pubmed/21283629
http://dx.doi.org/10.1371/journal.pone.0016427

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026010/
https://www.ncbi.nlm.nih.gov/pubmed/21283629
http://dx.doi.org/10.1371/journal.pone.0016427

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