Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema

We investigated the in vivo effects of a novel aquaporin 4 (AQP4) inhibitor 2-(nicotinamide)-1,3,4-thiadiazole, TGN-020, in a mouse model of focal cerebral ischemia using 7.0-T magnetic resonance imaging (MRI). Pretreatment with TGN-020 significantly reduced brain edema associated with brain ischemi...

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Detalles Bibliográficos
Autores principales: Igarashi, Hironaka, Huber, Vincent J., Tsujita, Mika, Nakada, Tsutomu
Formato: Texto
Lenguaje:English
Publicado: Springer Milan 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026762/
https://www.ncbi.nlm.nih.gov/pubmed/20924629
http://dx.doi.org/10.1007/s10072-010-0431-1
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author Igarashi, Hironaka
Huber, Vincent J.
Tsujita, Mika
Nakada, Tsutomu
author_facet Igarashi, Hironaka
Huber, Vincent J.
Tsujita, Mika
Nakada, Tsutomu
author_sort Igarashi, Hironaka
collection PubMed
description We investigated the in vivo effects of a novel aquaporin 4 (AQP4) inhibitor 2-(nicotinamide)-1,3,4-thiadiazole, TGN-020, in a mouse model of focal cerebral ischemia using 7.0-T magnetic resonance imaging (MRI). Pretreatment with TGN-020 significantly reduced brain edema associated with brain ischemia, as reflected by percentage of brain swelling volume (%BSV), 12.1 ± 6.3% in the treated group, compared to (20.8 ± 5.9%) in the control group (p < 0.05), and in the size of cortical infarction as reflected by the percentage of hemispheric lesion volume (%HLV), 20.0 ± 7.6% in the treated group, compared to 30.0 ± 9.1% in the control group (p < 0.05). The study indicated the potential pharmacological use of AQP4 inhibition in reducing brain edema associated with focal ischemia.
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spelling pubmed-30267622011-02-22 Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema Igarashi, Hironaka Huber, Vincent J. Tsujita, Mika Nakada, Tsutomu Neurol Sci Original Article We investigated the in vivo effects of a novel aquaporin 4 (AQP4) inhibitor 2-(nicotinamide)-1,3,4-thiadiazole, TGN-020, in a mouse model of focal cerebral ischemia using 7.0-T magnetic resonance imaging (MRI). Pretreatment with TGN-020 significantly reduced brain edema associated with brain ischemia, as reflected by percentage of brain swelling volume (%BSV), 12.1 ± 6.3% in the treated group, compared to (20.8 ± 5.9%) in the control group (p < 0.05), and in the size of cortical infarction as reflected by the percentage of hemispheric lesion volume (%HLV), 20.0 ± 7.6% in the treated group, compared to 30.0 ± 9.1% in the control group (p < 0.05). The study indicated the potential pharmacological use of AQP4 inhibition in reducing brain edema associated with focal ischemia. Springer Milan 2010-10-06 2011 /pmc/articles/PMC3026762/ /pubmed/20924629 http://dx.doi.org/10.1007/s10072-010-0431-1 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Article
Igarashi, Hironaka
Huber, Vincent J.
Tsujita, Mika
Nakada, Tsutomu
Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema
title Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema
title_full Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema
title_fullStr Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema
title_full_unstemmed Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema
title_short Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema
title_sort pretreatment with a novel aquaporin 4 inhibitor, tgn-020, significantly reduces ischemic cerebral edema
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026762/
https://www.ncbi.nlm.nih.gov/pubmed/20924629
http://dx.doi.org/10.1007/s10072-010-0431-1
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AT tsujitamika pretreatmentwithanovelaquaporin4inhibitortgn020significantlyreducesischemiccerebraledema
AT nakadatsutomu pretreatmentwithanovelaquaporin4inhibitortgn020significantlyreducesischemiccerebraledema

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