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Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1
We previously reported that global deletion of insulin receptor substrate protein 1 (Irs1) extends lifespan and increases resistance to several age-related pathologies in female mice. However, no effect on lifespan was observed in male Irs1 null mice. We suggested at the time that the lack of any ef...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026792/ https://www.ncbi.nlm.nih.gov/pubmed/21283571 http://dx.doi.org/10.1371/journal.pone.0016144 |