Gating of a pH-Sensitive K(2P) Potassium Channel by an Electrostatic Effect of Basic Sensor Residues on the Selectivity Filter

K(+) channels share common selectivity characteristics but exhibit a wide diversity in how they are gated open. Leak K(2P) K(+) channels TASK-2, TALK-1 and TALK-2 are gated open by extracellular alkalinization. The mechanism for this alkalinization-dependent gating has been proposed to be the neutra...

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Detalles Bibliográficos
Autores principales: Zúñiga, Leandro, Márquez, Valeria, González-Nilo, Fernando D., Chipot, Christophe, Cid, L. Pablo, Sepúlveda, Francisco V., Niemeyer, María Isabel
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026807/
https://www.ncbi.nlm.nih.gov/pubmed/21283586
http://dx.doi.org/10.1371/journal.pone.0016141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026807/
https://www.ncbi.nlm.nih.gov/pubmed/21283586
http://dx.doi.org/10.1371/journal.pone.0016141

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