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Gating of a pH-Sensitive K(2P) Potassium Channel by an Electrostatic Effect of Basic Sensor Residues on the Selectivity Filter
K(+) channels share common selectivity characteristics but exhibit a wide diversity in how they are gated open. Leak K(2P) K(+) channels TASK-2, TALK-1 and TALK-2 are gated open by extracellular alkalinization. The mechanism for this alkalinization-dependent gating has been proposed to be the neutra...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026807/ https://www.ncbi.nlm.nih.gov/pubmed/21283586 http://dx.doi.org/10.1371/journal.pone.0016141 |