Cargando…

Evaluation of the anti-angiogenic properties of the new selective α(V)β(3 )integrin antagonist RGDechiHCit

BACKGROUND: Integrins are heterodimeric receptors that play a critical role in cell-cell and cell-matrix adhesion processes. Among them, α(V)β(3 )integrin, that recognizes the aminoacidic RGD triad, is reported to be involved in angiogenesis, tissue repair and tumor growth. We have recently synthesi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santulli, Gaetano, Basilicata, Maria Felicia, De Simone, Mariarosaria, Del Giudice, Carmine, Anastasio, Antonio, Sorriento, Daniela, Saviano, Michele, Del Gatto, Annarita, Trimarco, Bruno, Pedone, Carlo, Zaccaro, Laura, Iaccarino, Guido
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027097/ https://www.ncbi.nlm.nih.gov/pubmed/21232121 http://dx.doi.org/10.1186/1479-5876-9-7

Ejemplares similares

RGDechi-hCit: αvβ3 Selective Pro-Apoptotic Peptide as Potential Carrier for Drug Delivery into Melanoma Metastatic Cells
por: Capasso, Domenica, et al.
Publicado: (2014)

Selective Targeting of αvβ5 Integrin in HepG2 Cell Line by RGDechi15D Peptide
por: Capasso, Domenica, et al.
Publicado: (2020)

High-Resolution Conformational Analysis of RGDechi-Derived Peptides Based on a Combination of NMR Spectroscopy and MD Simulations
por: Acconcia, Clementina, et al.
Publicado: (2022)

Age-Related Impairment in Insulin Release: The Essential Role of β(2)-Adrenergic Receptor
por: Santulli, Gaetano, et al.
Publicado: (2012)

CaMK4 Gene Deletion Induces Hypertension
por: Santulli, Gaetano, et al.
Publicado: (2012)

An Overview of Peptide-Based Molecules as Potential Drug Candidates for Multiple Sclerosis
por: Del Gatto, Annarita, et al.
Publicado: (2021)

A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment
por: Pirone, Luciano, et al.
Publicado: (2020)

Peptoids: Smart and Emerging Candidates for the Diagnosis of Cancer, Neurological and Autoimmune Disorders
por: Giorgio, Anna, et al.
Publicado: (2023)

Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization.
por: Sorriento, Daniela, et al.
Publicado: (2014)

A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFκB activity
por: Sorriento, Daniela, et al.
Publicado: (2009)

The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors
por: Sorriento, Daniela, et al.
Publicado: (2018)

Adrenergic Mechanism in the Control of Endothelial Function
por: Sorriento, Daniela, et al.
Publicado: (2011)

A Novel Small Peptide Inhibitor of NFκB, RH10, Blocks Oxidative Stress-Dependent Phenotypes in Cancer
por: Gambardella, Jessica, et al.
Publicado: (2018)

Dual role of GRK5 in cancer development and progression
por: Gambardella, J, et al.
Publicado: (2016)

Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells
por: Lombardi, Angela, et al.
Publicado: (2017)

Antidiabetic and Cardioprotective Effects of Pharmacological Inhibition of GRK2 in db/db Mice
por: Cipolletta, Ersilia, et al.
Publicado: (2019)

Cardiac Nonmyocyte Cell Functions and Crosstalks in Response to Cardiotoxic Drugs
por: Gambardella, Jessica, et al.
Publicado: (2017)

Targeting the CaMKII/ERK Interaction in the Heart Prevents Cardiac Hypertrophy
por: Cipolletta, Ersilia, et al.
Publicado: (2015)

The Antioxidant Therapy: New Insights in the Treatment of Hypertension
por: Sorriento, Daniela, et al.
Publicado: (2018)

“Freeze, Don’t Move”: How to Arrest a Suspect in Heart Failure – A Review on Available GRK2 Inhibitors
por: Sorriento, Daniela, et al.
Publicado: (2016)

Editorial: Peptidomimetics: Synthetic Tools for Drug Discovery and Development
por: Del Gatto, Annarita, et al.
Publicado: (2021)

Physical activity ameliorates cardiovascular health in elderly subjects: the functional role of the β adrenergic system
por: Santulli, Gaetano, et al.
Publicado: (2013)

Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure
por: Lombardi, Angela, et al.
Publicado: (2017)

Therapeutic Potential of a Novel α(v)β(3) Antagonist to Hamper the Aggressiveness of Mesenchymal Triple Negative Breast Cancer Sub-Type
por: Hill, Billy Samuel, et al.
Publicado: (2019)

New small molecules, ISA27 and SM13, inhibit tumour growth inducing mitochondrial effects of p53
por: Sorriento, D, et al.
Publicado: (2015)

Effects of Chronic Supplementation of L-Arginine on Physical Fitness in Water Polo Players
por: Gambardella, Jessica, et al.
Publicado: (2021)

Adrenergic receptors and metabolism: role in development of cardiovascular disease
por: Ciccarelli, Michele, et al.
Publicado: (2013)

Atrial fibrillation and microRNAs
por: Santulli, Gaetano, et al.
Publicado: (2014)

NFkappaB is a Key Player in the Crosstalk between Inflammation and Cardiovascular Diseases
por: Fiordelisi, Antonella, et al.
Publicado: (2019)

Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders
por: Sorriento, Daniela, et al.
Publicado: (2014)

Rays Sting: The Acute Cellular Effects of Ionizing Radiation Exposure
por: Franco, A, et al.
Publicado: (2016)

Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure
por: Ciccarelli, Michele, et al.
Publicado: (2020)

Inflammation and Cardiovascular Diseases: The Most Recent Findings
por: Sorriento, Daniela, et al.
Publicado: (2019)

Commentary: Studies in Zebrafish Demonstrate That CNNM2 and NT5C2 Are Most Likely the Causal Genes at the Blood Pressure-Associated Locus on Human Chromosome 10q24.32
por: Sorriento, Daniela, et al.
Publicado: (2020)

The Cardiovascular Phenotype in Fabry Disease: New Findings in the Research Field
por: Sorriento, Daniela, et al.
Publicado: (2021)

Modulation of Insulin Sensitivity by Exercise Training: Implications for Cardiovascular Prevention
por: Iaccarino, Guido, et al.
Publicado: (2020)

The GPIIIA PlA2 polymorphism is associated with an increased risk of cardiovascular adverse events
por: Galasso, Gennaro, et al.
Publicado: (2010)

In vivo properties of the proangiogenic peptide QK
por: Santulli, Gaetano, et al.
Publicado: (2009)

The Rationale of Neprilysin Inhibition in Prevention of Myocardial Ischemia-Reperfusion Injury during ST-Elevation Myocardial Infarction
por: Bellis, Alessandro, et al.
Publicado: (2020)

GRK2 moderates the acute mitochondrial damage to ionizing radiation exposure by promoting mitochondrial fission/fusion
por: Franco, Antonietta, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3i87rav5rgmt4tsair3l9ii9in