A Novel Role for ATM in Regulating Proteasome-Mediated Protein Degradation through Suppression of the ISG15 Conjugation Pathway

Ataxia Telangiectasia (A-T) is an inherited immunodeficiency disorder wherein mutation of the ATM kinase is responsible for the A-T pathogenesis. Although the precise role of ATM in A-T pathogenesis is still unclear, its function in responding to DNA damage has been well established. Here we demonst...

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Detalles Bibliográficos
Autores principales: Wood, Laurence M., Sankar, Surendran, Reed, Ryan E., Haas, Arthur L., Liu, Leroy F., McKinnon, Peter, Desai, Shyamal D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027683/
https://www.ncbi.nlm.nih.gov/pubmed/21298066
http://dx.doi.org/10.1371/journal.pone.0016422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027683/
https://www.ncbi.nlm.nih.gov/pubmed/21298066
http://dx.doi.org/10.1371/journal.pone.0016422

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