Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

OBJECTIVE: To determine the role of glucagon action in the metabolic phenotype of untreated insulin deficiency. RESEARCH DESIGN AND METHODS: We compared pertinent clinical and metabolic parameters in glucagon receptor-null (Gcgr(−/−)) mice and wild-type (Gcgr(+/+)) controls after equivalent destruct...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Young, Wang, May-Yun, Du, Xiu Quan, Charron, Maureen J., Unger, Roger H.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028337/
https://www.ncbi.nlm.nih.gov/pubmed/21270251
http://dx.doi.org/10.2337/db10-0426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028337/
https://www.ncbi.nlm.nih.gov/pubmed/21270251
http://dx.doi.org/10.2337/db10-0426

Ejemplares similares