Phosphatidylinositol-4-Phosphate-5-Kinase α Deficiency Alters Dynamics of Glucose-Stimulated Insulin Release to Improve Glucohomeostasis and Decrease Obesity in Mice

OBJECTIVE: Phosphatidylinositol-4-phosphate-5-kinase (PI4P5K) has been proposed to facilitate regulated exocytosis and specifically insulin secretion by generating phosphatidylinositol-4,5-bisphosphate (PIP(2)). We sought to examine the role of the α isoform of PI4P5K in glucohomeostasis and insulin...

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Detalles Bibliográficos
Autores principales: Huang, Ping, Yeku, Oladapo, Zong, Haihong, Tsang, Phyllis, Su, Wenjuan, Yu, Xiao, Teng, Shuzhi, Osisami, Mary, Kanaho, Yasunori, Pessin, Jeffrey E., Frohman, Michael A.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028345/
https://www.ncbi.nlm.nih.gov/pubmed/21270258
http://dx.doi.org/10.2337/db10-0614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028345/
https://www.ncbi.nlm.nih.gov/pubmed/21270258
http://dx.doi.org/10.2337/db10-0614

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