Cargando…

Phosphatidylinositol-4-Phosphate-5-Kinase α Deficiency Alters Dynamics of Glucose-Stimulated Insulin Release to Improve Glucohomeostasis and Decrease Obesity in Mice

OBJECTIVE: Phosphatidylinositol-4-phosphate-5-kinase (PI4P5K) has been proposed to facilitate regulated exocytosis and specifically insulin secretion by generating phosphatidylinositol-4,5-bisphosphate (PIP(2)). We sought to examine the role of the α isoform of PI4P5K in glucohomeostasis and insulin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Ping, Yeku, Oladapo, Zong, Haihong, Tsang, Phyllis, Su, Wenjuan, Yu, Xiao, Teng, Shuzhi, Osisami, Mary, Kanaho, Yasunori, Pessin, Jeffrey E., Frohman, Michael A.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028345/ https://www.ncbi.nlm.nih.gov/pubmed/21270258 http://dx.doi.org/10.2337/db10-0614

Ejemplares similares

Ca(2+) Influx through Store-operated Calcium Channels Replenishes the Functional Phosphatidylinositol 4,5-Bisphosphate Pool Used by Cysteinyl Leukotriene Type I Receptors
por: Alswied, Abdullah, et al.
Publicado: (2015)

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin α(IIb)β(3) Outside-in Signaling
por: Battram, Anthony M., et al.
Publicado: (2017)

Hypoxia Decreases Insulin Signaling Pathways in Adipocytes
por: Regazzetti, Claire, et al.
Publicado: (2009)

Insulin Growth Factor-2 Binding Protein 3 (IGF2BP3) Is a Glioblastoma-specific Marker That Activates Phosphatidylinositol 3-Kinase/Mitogen-activated Protein Kinase (PI3K/MAPK) Pathways by Modulating IGF-2
por: Suvasini, Ramaswamy, et al.
Publicado: (2011)

The Calcium-mobilizing Messenger Nicotinic Acid Adenine Dinucleotide Phosphate Participates in Sperm Activation by Mediating the Acrosome Reaction
por: Vasudevan, Sridhar R., et al.
Publicado: (2010)

Photoaffinity Labeling of High Affinity Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-Binding Proteins in Sea Urchin Egg
por: Walseth, Timothy F., et al.
Publicado: (2012)

TPC2 Proteins Mediate Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)- and Agonist-evoked Contractions of Smooth Muscle
por: Tugba Durlu-Kandilci, Nezahat, et al.
Publicado: (2010)

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation
por: Nebel, Merle, et al.
Publicado: (2013)

Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death
por: Nakajima, Hidemitsu, et al.
Publicado: (2017)

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart
por: Capel, Rebecca A., et al.
Publicado: (2015)

Uncoupling Protein 3 (UCP3) Modulates the Activity of Sarco/Endoplasmic Reticulum Ca(2+)-ATPase (SERCA) by Decreasing Mitochondrial ATP Production
por: De Marchi, Umberto, et al.
Publicado: (2011)

Protein Kinase A Regulatory Subunits in Human Adipose Tissue: Decreased R2B Expression and Activity in Adipocytes From Obese Subjects
por: Mantovani, Giovanna, et al.
Publicado: (2009)

Thiazolidinedione Treatment Decreases Oxidative Stress in Spontaneously Hypertensive Heart Failure Rats Through Attenuation of Inducible Nitric Oxide Synthase–Mediated Lipid Radical Formation
por: Kadiiska, Maria B., et al.
Publicado: (2012)

Brain Insulin Signaling Is Increased in Insulin-Resistant States and Decreases in FOXOs and PGC-1α and Increases in Aβ(1–40/42) and Phospho-Tau May Abet Alzheimer Development
por: Sajan, Mini, et al.
Publicado: (2016)

Insulin receptor cleavage induced by estrogen impairs insulin signaling
por: Yuasa, Tomoyuki, et al.
Publicado: (2021)

Cyclic GMP Kinase I Modulates Glucagon Release From Pancreatic α-Cells
por: Leiss, Veronika, et al.
Publicado: (2011)

Mapping Structural Determinants within Third Intracellular Loop That Direct Signaling Specificity of Type 1 Corticotropin-releasing Hormone Receptor
por: Punn, Anu, et al.
Publicado: (2012)

Pulsatile Hormonal Signaling to Extracellular Signal-regulated Kinase: EXPLORING SYSTEM SENSITIVITY TO GONADOTROPIN-RELEASING HORMONE PULSE FREQUENCY AND WIDTH
por: Perrett, Rebecca M., et al.
Publicado: (2014)

Pulsatile and Sustained Gonadotropin-releasing Hormone (GnRH) Receptor Signaling: DOES THE ERK SIGNALING PATHWAY DECODE GnRH PULSE FREQUENCY?
por: Armstrong, Stephen P., et al.
Publicado: (2010)

Elevated Carbon Dioxide Blunts Mammalian cAMP Signaling Dependent on Inositol 1,4,5-Triphosphate Receptor-mediated Ca(2+) Release
por: Cook, Zara C., et al.
Publicado: (2012)

Information Transfer in Gonadotropin-releasing Hormone (GnRH) Signaling: EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK)-MEDIATED FEEDBACK LOOPS CONTROL HORMONE SENSING
por: Garner, Kathryn L., et al.
Publicado: (2016)

Understanding How Components of a Ca(2+) Release-activated Ca(2+) Channel Function♦: The Extended Transmembrane Orai1 N-terminal (ETON) Region Combines Binding Interface and Gate for Orai1 Activation by STIM1
Publicado: (2013)

Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance : The Medical Research Council Ely Prospective Study 1990–2000
por: Forouhi, Nita G., et al.
Publicado: (2008)

Mechanism of Oxidative DNA Damage in Diabetes : Tuberin Inactivation and Downregulation of DNA Repair Enzyme 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine-DNA Glycosylase
por: Simone, Simona, et al.
Publicado: (2008)

Integrin-Associated Protein Association With Src Homology 2 Domain Containing Tyrosine Phosphatase Substrate 1 Regulates IGF-I Signaling In Vivo
por: Maile, Laura A., et al.
Publicado: (2008)

Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle
por: Morino, Katsutaro, et al.
Publicado: (2008)

Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress
por: Senokuchi, Takafumi, et al.
Publicado: (2008)

Human Adenovirus Type 36 Enhances Glucose Uptake in Diabetic and Nondiabetic Human Skeletal Muscle Cells Independent of Insulin Signaling
por: Wang, Zhong Q., et al.
Publicado: (2008)

Activation of Estrogen Receptor Is Crucial for Resveratrol-Stimulating Muscular Glucose Uptake via Both Insulin-Dependent and -Independent Pathways
por: Deng, Jen-Ying, et al.
Publicado: (2008)

siRNA-Mediated Reduction of Inhibitor of Nuclear Factor-κB Kinase Prevents Tumor Necrosis Factor-α–Induced Insulin Resistance in Human Skeletal Muscle
por: Austin, Reginald L., et al.
Publicado: (2008)

Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth
por: Klöting, Nora, et al.
Publicado: (2008)

Metabolically Favorable Remodeling of Human Adipose Tissue by Human Adenovirus Type 36
por: Rogers, Pamela M., et al.
Publicado: (2008)

Impact of Oxidative Stress and Peroxisome Proliferator–Activated Receptor γ Coactivator-1α in Hepatic Insulin Resistance
por: Kumashiro, Naoki, et al.
Publicado: (2008)

Dual Role of Interleukin-6 in Regulating Insulin Sensitivity in Murine Skeletal Muscle
por: Nieto-Vazquez, Iria, et al.
Publicado: (2008)

Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes
por: Xie, Zhonglin, et al.
Publicado: (2008)

Differential Distribution, Clustering, and Lateral Diffusion of Subtypes of the Inositol 1,4,5-Trisphosphate Receptor
por: Pantazaka, Evangelia, et al.
Publicado: (2011)

Hydrophobic Motif Phosphorylation Is Not Required for Activation Loop Phosphorylation of p70 Ribosomal Protein S6 Kinase 1 (S6K1)
por: Keshwani, Malik M., et al.
Publicado: (2011)

Submaximal Inhibition of Protein Kinase C Restores ADP-induced Dense Granule Secretion in Platelets in the Presence of Ca(2+)
por: Unsworth, Amanda J., et al.
Publicado: (2011)

Anchored Protein Kinase A Recruitment of Active Rac GTPase
por: Logue, Jeremy S., et al.
Publicado: (2011)

Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)(536) Phosphorylation
por: Zhao, Yanhua, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_7aebioatqlaep01pn2oqipvdv2