Hyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1β Transcription in Human Adipose Tissue

OBJECTIVE: Obesity is characterized by elevated levels of proinflammatory cytokines, including interleukin (IL)-1β, that contribute to the development of insulin resistance. In this study, we set out to investigate whether hyperglycemia drives IL-1β production and caspase-1 activation in murine and...

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Detalles Bibliográficos
Autores principales: Koenen, Tim B., Stienstra, Rinke, van Tits, Lambertus J., de Graaf, Jacqueline, Stalenhoef, Anton F.H., Joosten, Leo A.B., Tack, Cees J., Netea, Mihai G.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028351/
https://www.ncbi.nlm.nih.gov/pubmed/21270263
http://dx.doi.org/10.2337/db10-0266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028351/
https://www.ncbi.nlm.nih.gov/pubmed/21270263
http://dx.doi.org/10.2337/db10-0266

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